The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 18, 2025

Filed:

Aug. 03, 2022
Applicant:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inventors:

Daeyeon Lee, Wynnewood, PA (US);

Robert Leon Mauck, Philadelphia, PA (US);

George R Dodge, Philadelphia, PA (US);

Fuquan Tu, Philadelphia, PA (US);

Bhavana Mohanraj, Philadelphia, PA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/50 (2006.01); A61K 9/107 (2006.01); A61K 38/18 (2006.01); A61P 19/04 (2006.01); B01J 13/02 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5031 (2013.01); A61K 9/1075 (2013.01); A61K 9/5089 (2013.01); A61K 38/1841 (2013.01); A61P 19/04 (2018.01); B01J 13/02 (2013.01); A61K 9/0024 (2013.01);
Abstract

Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.


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