The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 18, 2025

Filed:

Feb. 08, 2024
Applicant:

Mapi Pharma Ltd., Ness Ziona, IL;

Inventors:

Shai Rubnov, Tel Aviv, IL;

Ehud Marom, Tel Aviv, IL;

Anna Gopin, Petah-Tiqwa, IL;

Assignee:

Mapi Pharma Ltd., Ness Ziona, IL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/496 (2006.01); A61K 9/08 (2006.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
A61K 31/496 (2013.01); A61K 9/08 (2013.01); A61K 47/6937 (2017.08);
Abstract

The present invention provides long-acting parenteral pharmaceutical compositions including a therapeutically effective amount of Cariprazine or salts thereof, in a depot form suitable for administering at a medically acceptable location in a subject in need thereof. The depot compositions are preferably in the form of in-situ implants suitable for subcutaneous or intramuscular administration and provide prolonged release of the Cariprazine active ingredient and/or its metabolites desmethyl Cariprazine (DCAR) and didesmethyl Cariprazine (DDCAR) for a period of at least 4 weeks following a single administration. The present invention further provides methods of use of the depot compositions for the treatment of schizophrenia, major depressive disorder, and bipolar disorder.


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