The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 18, 2025

Filed:

May. 17, 2023
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Charles P. Lin, Arlington, MA (US);

Hari Prasad Paudel, Boston, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/145 (2006.01); A61B 5/00 (2006.01); A61B 5/1455 (2006.01); G01N 15/01 (2024.01); G01N 15/10 (2024.01); G01N 15/14 (2024.01); G01N 15/1434 (2024.01); G02B 21/00 (2006.01); G02B 21/08 (2006.01); G02B 21/14 (2006.01); G02B 21/36 (2006.01); G02B 26/12 (2006.01);
U.S. Cl.
CPC ...
A61B 5/14535 (2013.01); A61B 5/0068 (2013.01); A61B 5/1455 (2013.01); G01N 15/1436 (2013.01); G01N 15/1468 (2013.01); G02B 21/002 (2013.01); G02B 21/0048 (2013.01); G02B 21/0056 (2013.01); G02B 21/0068 (2013.01); G02B 21/008 (2013.01); G02B 21/086 (2013.01); G02B 21/14 (2013.01); G02B 21/365 (2013.01); G02B 26/12 (2013.01); A61B 2562/0233 (2013.01); G01N 15/01 (2024.01); G01N 2015/1006 (2013.01); G01N 2015/144 (2013.01);
Abstract

Systems, methods, and apparatus for differential phase contrast microscopy by transobjective differential epi-detection of forward scattered light are provided. In some embodiments, a microscope objective comprises: a housing with mounting threads at a second end; optical components defining an optical axis, comprising: an objective lens mounted at a first end, configured to collect light from a sample placed in a field of view, the plurality of optical components create a pupil plane at a first distance along the optical axis at which rays having the same angle of incidence on the objective lens converge at the same radial distance from the optical axis; a photodetector within the housing offset from the optical axis at a second distance along the optical axis; and another photodetector within the housing at second distance along the optical axis and offset from the optical axis in the opposite direction from the first photodetector.


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