The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 11, 2025

Filed:

Jul. 28, 2022
Applicant:

Accuragen Holdings Limited, George Town, KY;

Inventors:

Malek Faham, Burlingame, CA (US);

Shengrong Lin, Fremont, CA (US);

Ling Fung Tang, San Francisco, CA (US);

Yontao Lu, Sunnyvale, CA (US);

Zhaohui Sun, Albany, CA (US);

Yingyu Wang, Mountain View, CA (US);

Li Weng, Fremont, CA (US);

Assignee:

ACCURAGEN HOLDINGS LIMITED, George Town, KY;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6869 (2018.01); C12Q 1/6827 (2018.01); C12Q 1/6858 (2018.01); C40B 50/06 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6869 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6858 (2013.01); C40B 50/06 (2013.01); C12Q 2521/501 (2013.01); C12Q 2535/139 (2013.01); C12Q 2537/143 (2013.01);
Abstract

In some aspects, the present disclosure provides methods for identifying sequence variants, as well as methods of determining copy number of a genetic locus in a sample. Systems and kits for performing methods of the disclosure, as well as compositions produced by or useful in methods of the disclosure are also provided. In some embodiments, methods comprise extending 3' ends of polynucleotides by adding one or more pre-determined nucleotides. In some embodiments, methods comprise use of a strand-tagging sequence.


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