The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 11, 2025

Filed:

Dec. 30, 2020
Applicant:

Roswell Biotechnologies, Inc., San Diego, CA (US);

Inventors:

Barry L. Merriman, La Jolla, CA (US);

Venkatesh Alagarswamy Govindaraj, San Diego, CA (US);

Paul Mola, San Diego, CA (US);

Tim Geiser, San Diego, CA (US);

Assignee:

Semicon Bio, San Diego, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6869 (2018.01); C07H 21/02 (2006.01); C12Q 1/00 (2006.01); C12Q 1/26 (2006.01); C12Q 1/48 (2006.01); C12Q 1/6825 (2018.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6869 (2013.01); C07H 21/02 (2013.01); C12Q 1/001 (2013.01); C12Q 1/002 (2013.01); C12Q 1/005 (2013.01); C12Q 1/26 (2013.01); C12Q 1/48 (2013.01); C12Q 1/485 (2013.01); C12Q 1/6825 (2013.01); G01N 33/5438 (2013.01); G01N 2333/9126 (2013.01);
Abstract

In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.


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