The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2025
Filed:
Nov. 29, 2022
Applicant:
Washington University, St. Louis, MO (US);
Inventors:
Jeffrey D. Milbrandt, St. Louis, MO (US);
Aaron DiAntonio, St. Louis, MO (US);
Kow Essuman, St. Louis, MO (US);
Xianrong Mao, St. Louis, MO (US);
Yo Sasaki, St. Louis, MO (US);
Dan Summers, St. Louis, MO (US);
Assignee:
Washington University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/20 (2006.01); A61K 31/4425 (2006.01); A61K 31/4706 (2006.01); A61K 31/473 (2006.01); A61K 31/4965 (2006.01); A61P 31/00 (2006.01); A61P 33/00 (2006.01); C07D 219/10 (2006.01); C07D 241/20 (2006.01); C07D 401/06 (2006.01); C12Q 1/34 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/34 (2013.01); A61K 31/4425 (2013.01); A61K 31/4706 (2013.01); A61K 31/473 (2013.01); A61K 31/4965 (2013.01); G01N 2333/924 (2013.01);
Abstract
The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology.