The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2025
Filed:
Oct. 10, 2018
Applicant:
Fate Therapeutics, Inc., San Diego, CA (US);
Inventors:
Bahram Valamehr, San Diego, CA (US);
Megan Robinson, San Diego, CA (US);
Assignee:
FATE THERAPEUTICS, INC., San Diego, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/074 (2010.01); A61K 35/12 (2015.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0696 (2013.01); A61K 35/12 (2013.01); C12N 15/85 (2013.01); C12N 2800/10 (2013.01);
Abstract
Provided are methods and compositions for inducing the reprogramming of a non-pluripotent to an iPSC having desirable properties using a vector system providing transient and temporal expression of transgenes that are short-lived. Also provided are reprogramming cells and iPSC populations or clonal cell lines using the provided reprogramming methods and compositions. Further provided are genome-engineered iPSCs and derived cells redifferentiated therefrom to comprise targeted editing involving insertions and deletions in one or more selected genomic loci.