The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2025
Filed:
Jun. 21, 2023
Applicant:
Nantbio, Inc., Culver City, CA (US);
Inventors:
Kayvan Niazi, Culver City, CA (US);
Wael Tadros, Culver City, CA (US);
Annie Shin, Culver City, CA (US);
Assignee:
NantBio, Inc., Culver City, CA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 39/00 (2006.01); C07K 14/575 (2006.01); C07K 14/725 (2006.01); C07K 19/00 (2006.01); C12N 5/078 (2010.01); C12N 15/10 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C07K 19/00 (2013.01); A61K 39/00 (2013.01); A61K 39/001182 (2018.08); A61K 39/461 (2023.05); A61K 39/4622 (2023.05); A61K 39/464482 (2023.05); C07K 14/575 (2013.01); C07K 14/7051 (2013.01); C12N 15/102 (2013.01); C12N 15/86 (2013.01); C07K 2319/912 (2013.01); C12N 2710/10111 (2013.01);
Abstract
Compositions and methods are presented that allow for an enhanced immune response against a GPI-anchored tumor associated antigen by modification of the protein portion of the TAA to include a transmembrane domain and a trafficking signal that directs the modified protein to the endosomal or lysosomal compartment. Most preferably, the modified protein will no longer have a GPI anchor or GPI attachment sequence.