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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12247081 B1

PDFFull Text
Date of Patent:
Mar. 11, 2025

Filed:

May. 08, 2024

Ceacam5-dependent 4-1bb-agonistic bispecific antibodies

Applicant:

Lanova Medicines Limited, Shanghai, CN;

Inventors:

Runsheng Li, Shanghai, CN;

Wei Cao, Shanghai, CN;

Ying Qin Zang, Shanghai, CN;

Wentao Huang, Shanghai, CN;

Assignee:

LANOVA MEDICINES LIMITED, Shanghai, CN;

Attorney:

Sheppard, Mullin, Richter & Hampton LLP

Primary Examiner:

Daniel E Kolker

Assistant Examiner:

Maureen Varina Driscoll

Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2878 (2013.01); A61P 35/00 (2018.01); C07K 16/3007 (2013.01); A61K 2039/505 (2013.01); C07K 2317/22 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/52 (2013.01); C07K 2317/569 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01);
Abstract

Provided are bispecific or multispecific antibodies that include an anti-CEACAM5 portion and one or more anti-4-1BB nanobodies whose agonist activity is dependent on the presence of the CEACAM5 antigen. Such bispecific or multispecific antibodies are safe, and are efficacious in treating cancer and have long-term protective immunological memory against tumors. Methods of using the antibodies for treating diseases such as cancer are also provided.

Find Patent Forward Citations

Li, Runsheng. (2025). Ceacam5-dependent 4-1bb-agonistic bispecific antibodies (U.S. Patent No. 12247081). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12247081

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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