The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2025
Filed:
Apr. 27, 2023
Applicant:
Asher Biotherapeutics, Inc., South San Francisco, CA (US);
Inventors:
Yik Andy Yeung, South San Francisco, CA (US);
Renee L. Greer, Pacifica, CA (US);
Henry C. Nguyen, San Francisco, CA (US);
David Liu, Pacifica, CA (US);
Byong Kang, San Francisco, CA (US);
Ivana Djuretic, Pacifica, CA (US);
Assignee:
ASHER BIOTHERAPEUTICS, INC., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/24 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/54 (2006.01); C07K 16/28 (2006.01); C07K 16/40 (2006.01);
U.S. Cl.
CPC ...
C07K 16/244 (2013.01); A61P 35/00 (2018.01); C07K 14/54 (2013.01); C07K 16/2815 (2013.01); C07K 16/40 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/522 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/565 (2013.01); C07K 2317/64 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C07K 2319/74 (2013.01);
Abstract
The present disclosure provides methods and compositions comprising IL-21 polypeptides, targeted cytokine construct that selectively activates target immune cells (e.g., CD8+ T cells) over other immune cell types. The cytokine of the present disclosure can further comprise mutations that alter its charge distribution to improve its half-life within the blood.