The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2025
Filed:
Dec. 08, 2015
Applicant:
1globe Biomedical Co., Ltd., Beijing, CN;
Inventors:
Chiang J. Li, Cambridge, MA (US);
Shyam Unniraman, Newton, MA (US);
Assignee:
1GLOBE BIOMEDICAL CO., LTD., Beijing, CN;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/735 (2006.01); C07K 16/28 (2006.01); C07K 16/46 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70535 (2013.01); C07K 16/2806 (2013.01); C07K 16/2809 (2013.01); C07K 16/46 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/622 (2013.01); C07K 2317/732 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01); C07K 2319/74 (2013.01);
Abstract
Novel synthetic biology-based ADCC technologies are provided that enhance or enable ADCC responses, for example, through a rationally-designed soluble universal ADCC enhancer protein (SUAEP) where a high-affinity CD3-binding domain is fused to a high-affinity Fc-binding domain. The SUAEP technology can be used to prevent or treat cancers, infectious, inflammatory or autoimmune diseases, and other diseases where elimination of diseased cells is desirable.