The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 11, 2025

Filed:

Dec. 20, 2021
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Paul E. Morin, Pennington, NJ (US);

Daniel Cohen, New York, NY (US);

Ranjan Mukherjee, Churchville, PA (US);

Timothy P. Reilly, New Hope, PA (US);

Rose C. Christian, Hopewell, NJ (US);

Dasa Lipovsek, Pepperell, MA (US);

Ray Camphausen, Wayland, MA (US);

John Krupinski, Flemington, NJ (US);

Assignee:

BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/12 (2006.01); A61K 38/18 (2006.01); A61K 45/06 (2006.01); A61K 47/60 (2017.01); A61K 47/64 (2017.01); C07K 14/50 (2006.01); C12N 5/10 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/50 (2013.01); A61K 38/1825 (2013.01); A61K 45/06 (2013.01); A61K 47/60 (2017.08); A61K 47/64 (2017.08); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01);
Abstract

Nucleic acids encoding modified FGF-21 polypeptides, optionally containing at least one non-codon encoding a naturally-encoded amino acid, and vectors and cells containing are provided. These nucleic acids can be used to express the modified FGF-21 polypeptide encoded thereby. The expressed FGF-21 polypeptides may be used as therapeutics, e.g., in the treatment of diseases associated with fibrosis.


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