The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2025
Filed:
Aug. 10, 2022
Applicant:
Translate Bio, Inc., Waltham, MA (US);
Inventors:
Frank DeRosa, Waltham, MA (US);
Michael Heartlein, Waltham, MA (US);
Assignee:
Translate Bio, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/67 (2006.01); C07H 21/02 (2006.01); A61K 9/1271 (2025.01); A61K 9/1272 (2025.01);
U.S. Cl.
CPC ...
C07H 21/02 (2013.01); C12N 15/67 (2013.01); A61K 9/1271 (2013.01); A61K 9/1272 (2013.01); C12N 2310/3515 (2013.01);
Abstract
Disclosed are messenger RNA molecules and related compositions incorporating a 4'-thio modification in the furanose ring of at least one nucleotide residue, and methods of using these mRNAs to produce an encoded therapeutic protein in vivo and to treat or prevent diseases or disorders. In certain embodiments, the 4′-thio modified mRNA provides for enhanced stability and/or reduced immunogenicity in in vivo therapies.