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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12247011 B1

PDFFull Text
Date of Patent:
Mar. 11, 2025

Filed:

Jul. 31, 2018

Selective inhibitors of nlrp3 inflammasome

Applicant:

Nodthera Limited, Little Chesterford, GB;

Inventors:

Mark G. Bock, Lexington, MA (US);

David Harrison, Little Chesterford, GB;

Alan Paul Watt, Essex, GB;

Roderick Alan Porter, Hertfordshire, GB;

Nicolas Felix Pierre Boutard, Cracow, PL;

Charles-Henry Robert Yves Fabritius, Poznan, PL;

Grzegorz Witold Topolnicki, Piekary Slaskie, PL;

Oleksandr Levenets, Cracow, PL;

Assignee:

NodThera Limited, Little Chesterford, GB;

Attorneys:

COOLEY LLP

Heidi A. Erlacher

Christine E. Dunne

Primary Examiner:

Alicia L Otton

Int. Cl.
CPC ...
C07D 231/12 (2006.01); A61P 37/06 (2006.01); C07C 45/68 (2006.01); C07C 201/14 (2006.01); C07C 209/36 (2006.01); C07C 263/10 (2006.01); C07C 271/28 (2006.01); C07C 271/30 (2006.01); C07D 213/55 (2006.01); C07D 231/14 (2006.01); C07D 233/60 (2006.01); C07D 237/08 (2006.01); C07D 239/26 (2006.01); C07D 241/12 (2006.01); C07D 241/24 (2006.01); C07D 249/08 (2006.01); C07D 307/79 (2006.01); C07D 309/12 (2006.01); C07D 409/12 (2006.01); C07D 493/04 (2006.01);
U.S. Cl.
CPC ...
C07D 231/12 (2013.01); A61P 37/06 (2018.01); C07C 45/68 (2013.01); C07C 201/14 (2013.01); C07C 209/36 (2013.01); C07C 263/10 (2013.01); C07C 271/28 (2013.01); C07C 271/30 (2013.01); C07D 213/55 (2013.01); C07D 231/14 (2013.01); C07D 233/60 (2013.01); C07D 237/08 (2013.01); C07D 239/26 (2013.01); C07D 241/12 (2013.01); C07D 241/24 (2013.01); C07D 249/08 (2013.01); C07D 307/79 (2013.01); C07D 309/12 (2013.01); C07D 409/12 (2013.01); C07D 493/04 (2013.01);
Abstract

The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory and autoimmune diseases and cancers.

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