The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2025
Filed:
Mar. 10, 2017
Applicant:
Institute for Systems Biology, Seattle, WA (US);
Inventors:
Jie Luo, Seattle, WA (US);
Jeff Ranish, Seattle, WA (US);
Assignee:
Institute for Systems Biology, Seattle, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 207/416 (2006.01); C07D 207/46 (2006.01); C07D 513/04 (2006.01); G01N 33/60 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07D 207/416 (2013.01); C07D 207/46 (2013.01); C07D 513/04 (2013.01); G01N 33/60 (2013.01); G01N 33/6845 (2013.01); G01N 33/6848 (2013.01); G01N 33/6851 (2013.01); G01N 2458/15 (2013.01); G01N 2560/00 (2013.01);
Abstract
Crosslinking molecules that permit efficient identification of specifically associated proteins and the sites of crosslinking in biological or other samples include two cleavable bonds that are cleavable under the same conditions as peptide bonds in mass spectrometric determinations. Sets of the invention crosslinkers may be provided with isobaric labels containing reporter ions of differing molecular weights to permit relative quantitation of crosslinked protein pairs.