The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 11, 2025

Filed:

Nov. 17, 2023
Applicants:

Provincial Health Services Authority, Vancouver, CA;

The University of British Columbia, Vancouver, CA;

Inventors:

Kuo-Shyan Lin, Richmond, CA;

François Bénard, Vancouver, CA;

Lei Wang, Vancouver, CA;

Zhengxing Zhang, Langley, CA;

Ivica Bratanovic, Port Moody, CA;

Chengcheng Zhang, Richmond, CA;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61K 51/08 (2006.01); A61M 36/14 (2006.01);
U.S. Cl.
CPC ...
A61K 51/088 (2013.01); A61K 2121/00 (2013.01); A61K 2123/00 (2013.01);
Abstract

There is provided peptidic compounds of Formula I, A or B(R-[linker]-R-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-ψ-Xaa-NH). Xaais D-Phe, Cpa, D-Cpa, Nal, D-Nal, 2-Nal, or D-2-Nal; Xaais Asn, Gln, Hse, Cit or His. Xaais Trp, Bta, Trp(Me), Trp(7-Me), Trp(6-Me), Trp(5-Me), Trp(4-Me), Trp(2-Me), Trp(7-F), Trp(6-F), Trp(5-F), Trp(4-F), Trp(5-OH), or αMe-Trp. Xaais Ala or Ser. Xaais Val, Cpg, or Tle. Xaais Gly, NMe-Gly, or D-Ala. Xaais His or NMe-His. Xaais Leu or Phe. Xaa-NHis a C-terminally amidated amino acid residue selected from Pro, 4-oxa-L-Pro, MeThz, or Thz. ψ represents a peptide bond or reduced peptide bond joining Xaato Xaa. Ris 1-5 radiolabeling groups. There is also provided the use of such compounds as imaging agents or therapeutic agents.


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