The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2025
Filed:
Mar. 26, 2020
Applicant:
University of Cincinnati, Cincinnati, OH (US);
Inventors:
Joo-Youp Lee, Cincinnati, OH (US);
Edward Merino, Cincinnati, OH (US);
Vishnu Sriram, Cincinnati, OH (US);
Mina Jafari, Cincinnati, OH (US);
Assignee:
University of Cincinnati, Cincinnati, OH (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/59 (2017.01); A61K 47/54 (2017.01); A61K 47/60 (2017.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/593 (2017.08); A61K 47/54 (2017.08); A61K 47/60 (2017.08); A61P 35/00 (2018.01);
Abstract
A novel ROS-responsive prodrug is provided. The prodrug utilizes a unique modified oxalate linker conjugated to 4-aminophenol, which can enhance the reaction kinetics for intracellular ROS within tumor tissues while keeping the modified oxalate backbone stable with amide bond under very low ROS level.