The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2025
Filed:
Jan. 04, 2018
Applicant:
Brandeis University, Waltham, MA (US);
Inventors:
Bing Xu, Newton, MA (US);
Huaimin Wang, Waltham, MA (US);
Assignee:
BRANDEIS UNIVERSITY, Waltham, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/54 (2017.01); A61K 38/00 (2006.01); A61K 47/42 (2017.01); A61P 35/00 (2006.01); C07K 5/107 (2006.01);
U.S. Cl.
CPC ...
A61K 47/548 (2017.08); A61K 47/42 (2013.01); A61P 35/00 (2018.01); C07K 5/1016 (2013.01); A61K 38/00 (2013.01);
Abstract
Disclosed are peptides capable of enzymatically-induced self-assembly to which is conjugated a redox modulator. These peptides are enzymatically responsive hydrogelators, and they can be used to form pericellular hydrogels/nanofibrils upon exposure to target cells that secrete or express a surface bound ectoenzyme having hydrolase activity suitable to induce peptide gelation. These materials, and compositions containing the same, can be used for inhibiting cancer cell migration, inhibiting cancer cell survival, and/or inhibiting cancer cell growth.