The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2025
Filed:
May. 15, 2018
Amicus Therapeutics, Inc., Cranbury, NJ (US);
Hung Do, New Hope, PA (US);
Russell Gotschall, Doylestown, PA (US);
Richie Khanna, Somerset, NJ (US);
Yi Lun, Plainsboro, NJ (US);
Hing Char, East Brunswick, NJ (US);
Sergey Tesler, Monroe, NJ (US);
Wendy Sunderland, Doylestown, PA (US);
Enrique Diloné, Basking Ridge, NJ (US);
Amicus Therapeutics, Inc., Philadelphia, PA (US);
Abstract
Provided are a recombinant acid α-glucosidase and pharmaceutical composition comprising a recombinant acid α-glucosidase, wherein the recombinant acid α-glucosidase is expressed in Chinese hamster ovary (CHO) cells and comprises an increased content of N-glycan units bearing one or two mannose-6-phosphate residues when compared to a content of N-glycan units bearing one or two mannose-6-phosphate residues of alglucosidase alfa. Also provided herein are methods of producing, purifying, and formulating the recombinant acid α-glucosidase or pharmaceutical composition for administration to a subject and methods of treating a disease or disorder such as Pompe disease using the recombinant acid α-glucosidase or pharmaceutical composition.