The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 11, 2025

Filed:

Dec. 02, 2019
Applicant:

Merck Sharp & Dohme Llc, Rahway, NJ (US);

Inventors:

Christopher J. Bungard, Lansdale, PA (US);

Helen Y. Chen, Marlboro, NJ (US);

Jason M. Cox, Flemington, NJ (US);

Liangqin Guo, Monroe Township, NJ (US);

Michael J. Kelly, III, Paoli, PA (US);

Ronald M. Kim, Summit, NJ (US);

Mark E. Layton, Harleysville, PA (US);

Hong Liu, Hillsborough, NJ (US);

Jian Liu, Edison, NJ (US);

Mehul F. Patel, Blue Bell, PA (US);

James J. Perkins, Churchville, PA (US);

Deping Wang, Furlong, PA (US);

Walter Won, San Diego, CA (US);

Younong Yu, East Brunswick, NJ (US);

Ting Zhang, Princeton Junction, NJ (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/433 (2006.01); A61K 31/167 (2006.01); A61K 31/4439 (2006.01); A61K 31/505 (2006.01); A61K 31/5377 (2006.01); C07D 239/42 (2006.01); C07D 285/08 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/433 (2013.01); A61K 31/167 (2013.01); A61K 31/4439 (2013.01); A61K 31/505 (2013.01); A61K 31/5377 (2013.01); C07D 239/42 (2013.01); C07D 285/08 (2013.01); C07D 417/12 (2013.01);
Abstract

Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.


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