The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2025
Filed:
Jun. 03, 2019
The Broad Institute, Inc., Cambridge, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Instituto Carlos Slim DE LA Salud, A.c., Colonia Granada Ampliacion, MX;
Francisca Vazquez, Cambridge, MA (US);
Adam Bass, Boston, MA (US);
Tsukasa Shibue, Cambridge, MA (US);
Edmond Chan, Boston, MA (US);
James McFarland, Cambridge, MA (US);
Mahmoud Ghandi, Cambridge, MA (US);
Aviad Tsherniak, Cambridge, MA (US);
THE BROAD INSTITUTE, INC., Cambridge, MA (US);
INSTITUTO CARLOS SLIM DE LA SALUD, A.C., D.F., MX;
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Abstract
The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of microsatellite unstable cancers. In particular, the instant disclosure provides for identification of a cancer as exhibiting microsatellite instability (MSI) and/or impaired mismatch repair (MMR), and selection and/or administration of an inhibitor of the WRN helicase as a therapeutic agent for such a cancer and/or subject having or at risk of developing such a cancer.