The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 04, 2025

Filed:

Jan. 08, 2019
Applicant:

Illumina, Inc., San Diego, CA (US);

Inventor:

Thomas Baker, San Diego, CA (US);

Assignee:

Illumina, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 21/64 (2006.01); G02B 5/18 (2006.01); G02B 21/00 (2006.01); G02B 21/06 (2006.01); G02B 21/08 (2006.01); G02B 21/16 (2006.01); G02B 21/36 (2006.01);
U.S. Cl.
CPC ...
G01N 21/6428 (2013.01); G01N 21/6454 (2013.01); G01N 21/6456 (2013.01); G02B 21/0032 (2013.01); G02B 21/06 (2013.01); G02B 21/082 (2013.01); G02B 21/16 (2013.01); G02B 21/361 (2013.01); G01N 21/6458 (2013.01); G01N 2021/6463 (2013.01); G01N 2201/0635 (2013.01); G02B 5/1866 (2013.01);
Abstract

The disclosure provides a structured illumination imaging system that utilizes an image sensor (e.g., an active pixel sensor) in an active plane of a patterned sample to increase image resolution. The imaged sample may be patterned and/or aligned over an image sensor such that each light sensor (e.g., pixel) of the image sensor has a respective plurality of features formed and/or mounted above it. In response to illumination, each of the features may emit fluorescent light that is collected by a pixel of the image sensor. During imaging, each pixel of the image sensor may be spatially multiplexed using structured illumination such that only a subset (e.g., one or two) of the features aligned over the pixel are illuminated with structured light during an image read.


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