The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 04, 2025

Filed:

Dec. 08, 2020
Applicant:

The Board of Regents of the University of Oklahoma, Norman, OK (US);

Inventors:

Anne Kasus-Jacobi, Midwest City, OK (US);

Heloise Anne Pereira, Edmond, OK (US);

Amanda J. Stock, Nottingham, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); A61K 38/00 (2006.01); A61K 38/48 (2006.01); A61P 25/28 (2006.01); C07K 14/47 (2006.01); C12N 9/64 (2006.01); C12N 9/96 (2006.01);
U.S. Cl.
CPC ...
C12N 9/6424 (2013.01); A61K 38/482 (2013.01); A61K 38/486 (2013.01); A61P 25/28 (2018.01); C07K 14/4723 (2013.01); C12N 9/6448 (2013.01); C12N 9/96 (2013.01); C12Y 304/2102 (2013.01); C12Y 304/21037 (2013.01); A61K 38/00 (2013.01);
Abstract

Peptide compounds derived from cathepsin G (CG), neutrophil elastase (NE), and cationic antimicrobial protein of 37 kDa (CAP37), and methods of their use in inhibiting and/or reversing polymerization of amyloid β peptide into oligomers and/or fibrils, and/or disaggregating amyloid β plaques, and methods of use of the peptide compounds in treatments of, for example, Alzheimer's disease, cerebral amyloid angiopathy, dementia, and/or neuroinflammation, and/or symptoms thereof are disclosed.


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