The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2025
Filed:
Jan. 11, 2019
Bristol-myers Squibb Company, Princeton, NJ (US);
Roche Innovation Center Copenhagen A/s, Hørsholm, DK;
Richard E. Olson, Cambridge, MA (US);
Angela M. Cacace, Haddam Neck, CT (US);
Jere E. Meredith, Jr., Haddam, CT (US);
Nino Devidze, Conshohocken, PA (US);
James K. Loy, Gales Ferry, CT (US);
Carl J. Baldick, Pennington, NJ (US);
Annapurna Pendri, South Glastonbury, CT (US);
Ivar M. McDonald, Woodstock, CT (US);
Peter Hagedorn, Hørsholm, DK;
Marianne Lerbech Jensen, Køge, DK;
Bristol-Myers Squibb Company, Princeton, NJ (US);
Roche Innovation Center Copenhagen A/S, Hørsholm, DK;
Abstract
The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.