The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 04, 2025

Filed:

May. 30, 2019
Applicants:

Ono Pharmaceutical Co., Ltd., Osaka, JP;

National Cancer Center, Tokyo, JP;

Inventors:

Hiroyoshi Nishikawa, Chiba, JP;

Yosuke Togashi, Chiba, JP;

Yukiya Ohyama, Osaka, JP;

Takao Yoshida, Osaka, JP;

Kazuhiko Takeda, Osaka, JP;

Kenichi Koda, Osaka, JP;

Atsushi Honda, Osaka, JP;

Atsushi Oyagi, Osaka, JP;

Toru Kakinuma, Osaka, JP;

Masayuki Murata, Osaka, JP;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2818 (2013.01); A61P 35/00 (2018.01); G01N 33/505 (2013.01); A61K 2039/507 (2013.01); G01N 2800/52 (2013.01);
Abstract

A method for identifying a patient with malignant tumor on which the effect of an immune checkpoint inhibitor can be more expected, and agents for suppressing the progression of, suppressing the recurrence of, and/or treating malignant tumor, characterized by prescriptions based on identifying a patient with a malignant tumor on which the effect of an immune checkpoint inhibitor can be more expected, by analyzing evaluation items including combinations such as the PD-1 expression intensity, the percentage of the number of PD-1 expressing cells and the like in Treg cells and CD8T cells in tumor tissue or blood.


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