The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2025
Filed:
Dec. 07, 2018
Applicant:
Argenx Bv, Ghent, BE;
Inventors:
Johannes De Haard, Oudelande, NL;
Torsten Dreier, Sint-Martens-Latem, BE;
Peter Ulrichts, Destelbergen, BE;
Antonio Guglietta, Barcelona, ES;
Nicolas Leupin, Zurich, CH;
Assignee:
argenx BV, Ghent, BE;
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61P 37/00 (2006.01); C07K 14/47 (2006.01); C07K 14/735 (2006.01); C07K 16/00 (2006.01); A61K 9/00 (2006.01); A61K 38/00 (2006.01); A61K 45/06 (2006.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4703 (2013.01); A61P 37/00 (2018.01); C07K 14/70535 (2013.01); C07K 16/00 (2013.01); A61K 9/0019 (2013.01); A61K 38/00 (2013.01); A61K 45/06 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01); C07K 2317/52 (2013.01); C07K 2317/526 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/30 (2013.01);
Abstract
Provided are novel methods of treating generalized myasthenia gravis in a subject. These methods generally comprise administering to the subject an effective amount of an isolated FcRn antagonist. In certain embodiments the FcRn antagonist binds to FcRn with increased affinity and reduced pH dependence relative to native Fc region.