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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12240836 B1

PDFFull Text
Date of Patent:
Mar. 04, 2025

Filed:

Jul. 05, 2022

Compounds as gcninhibitors, pharmaceutical compositions and uses thereof

Applicant:

Dong-a St Co., Ltd., Seoul, KR;

Inventors:

Cheonhyoung Park, Seoul, KR;

Kimoon Ryu, Yongin-si, KR;

Tae-Hun Kim, Seoul, KR;

Ha Yoon Kim, Hwaseong-si, KR;

Eunhye Ju, Suwon-si, KR;

Hyung Ki Lee, Hwaseong-si, KR;

Youngjee Jeong, Seongnam-si, KR;

Doyoung Choi, Seoul, KR;

Jun Hwan Moon, Yongin-si, KR;

Nayeon Park, Suwon-si, KR;

Iksoo Jang, Seongnam-si, KR;

Kyu Hwan Kim, Suwon-si, KR;

Hyangsoo Lee, Seoul, KR;

Min Jung Lee, Yongin-si, KR;

Assignee:

Dong-A ST Co., Ltd., Seoul, KR;

Attorney:

NIXON & VANDERHYE, PC

Primary Examiner:

Clinton A Brooks

Assistant Examiner:

Jerica Katlynn Wilson

Int. Cl.
CPC ...
C07D 403/14 (2006.01); A61K 31/506 (2006.01); A61K 31/53 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); A61P 35/00 (2006.01); C07D 401/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 403/14 (2013.01); A61K 31/506 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61P 35/00 (2018.01); C07D 401/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01);
Abstract

Provided herein are novel compounds, e.g., those of Formula (I), as GCN2 inhibitors. Also provided are pharmaceutical compositions including one or more of the novel compounds, and pharmaceutical uses thereof. Compounds provided herein can typically inhibit an activity of a GCN2 and thus can be used for treating or preventing diseases related thereto.

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