The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2025
Filed:
May. 29, 2019
Applicant:
Translate Bio, Inc., Lexington, MA (US);
Inventors:
Yi Zhang, Lexington, MA (US);
Shrirang Karve, Lexington, MA (US);
Saswata Karmakar, Lexington, MA (US);
Frank DeRosa, Lexington, MA (US);
Michael Heartlein, Lexington, MA (US);
Assignee:
TRANSLATE BIO, INC., Waltham, MA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 401/00 (2006.01); A61K 9/127 (2006.01); C07C 225/14 (2006.01); C07C 229/12 (2006.01); C07C 323/25 (2006.01); C07C 323/27 (2006.01); C07C 403/12 (2006.01); C07D 311/20 (2006.01); A61K 31/592 (2006.01); A61K 31/593 (2006.01);
U.S. Cl.
CPC ...
C07D 311/20 (2013.01); C07C 225/14 (2013.01); C07C 229/12 (2013.01); C07C 323/25 (2013.01); C07C 323/27 (2013.01); C07C 403/12 (2013.01); C07C 2601/14 (2017.05); C07C 2601/16 (2017.05); C07C 2602/24 (2017.05);
Abstract
Disclosed are cationic lipids comprising a vitamin substructure and an ionizable nitrogen-containing group. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.