The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2025
Filed:
Jun. 05, 2020
Applicant:
Asklepion Pharmaceuticals, Llc, Baltimore, MD (US);
Inventors:
James Alan Bull, Freiburg, DE;
Holger Christian Fischer, Freiburg, DE;
Karl Juergen Kaiser, Freiburg, DE;
Bette Monnot-Chase, Baltimore, MD (US);
Assignee:
ASKLEPION PHARMACEUTICALS, LLC, Baltimore, MD (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 273/16 (2006.01); A61K 9/00 (2006.01); C07C 273/18 (2006.01);
U.S. Cl.
CPC ...
C07C 273/1809 (2013.01); A61K 9/0029 (2013.01); C07C 273/16 (2013.01);
Abstract
This invention provides for synthesis of citrulline from a transition metal complex of ornithine using cyanate to derivatize the terminal amino group of ornithine. The invention also provides improved methods for purification of citrulline produced by reaction of cyanate with ornithine via the steps of reprecipitation of copper complex of citrulline, removal of the complexing metal by sulfide precipitation, activated carbon adsorption and antisolvent crystallization.