The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2025
Filed:
Apr. 29, 2019
Applicant:
The Medical College of Wisconsin, Inc., Milwaukee, WI (US);
Inventors:
Jeffrey A. Medin, Shorewood, WI (US);
Daniel H. Fowler, Milwaukee, WI (US);
Murtaza S. Nagree, Milwaukee, WI (US);
Tania Felizardo, Milwaukee, WI (US);
Assignee:
The Medical College of Wisconsin, Inc., Milwaukee, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 35/17 (2015.01); A61K 38/44 (2006.01); A61K 38/47 (2006.01); A61K 39/00 (2006.01); A61P 43/00 (2006.01); C12N 5/0783 (2010.01); C12N 15/63 (2006.01); C12N 15/79 (2006.01);
U.S. Cl.
CPC ...
A61K 38/443 (2013.01); A61K 38/47 (2013.01); A61K 39/4611 (2023.05); A61K 39/464 (2023.05); A61P 43/00 (2018.01); C12N 5/0636 (2013.01); C12N 15/86 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C12N 15/79 (2013.01); C12N 2510/00 (2013.01); C12Y 101/01205 (2013.01); C12Y 302/01022 (2013.01);
Abstract
The present disclosure provides methods of treating lysosomal storage disorders, e.g., Fabry disease, Gaucher disease, Farber disease, and Pompe disease. The method comprises producing vector-transduced T-Rapa cells that express a transgene of interest and administering the cells to a patient in need thereof. The T-Rapa cells may be transduced with a dual promoter lentivirus vector.