The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2025
Filed:
Mar. 19, 2024
Applicant:
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Inventors:
Assignee:
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7028 (2006.01); A61K 31/19 (2006.01); A61K 31/365 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7028 (2013.01); A61K 31/19 (2013.01); A61K 31/365 (2013.01); A61K 45/06 (2013.01);
Abstract
Compositions for regeneration of inner cells and for treating hearing loss comprise at least one modulator of mechanistic target of rapamycin (mTOR) sufficient to induce reprogramming proliferation and regeneration of inner ear cells. The composition include, in some instances, an effective amount of one or more phosphatase and tensin homolog (PTEN) inhibitors, MYC/NOTCH modulators, Atonal Homolog 1 (Atoh1) modulators or combinations thereof.