The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2025
Filed:
Sep. 25, 2020
Applicant:
Rajeshwar Mookerjee, London, GB;
Inventor:
Rajeshwar Mookerjee, London, GB;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/475 (2006.01); A61K 31/4178 (2006.01); A61P 1/16 (2006.01); C12Q 1/6876 (2018.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A61K 31/475 (2013.01); A61K 31/4178 (2013.01); A61P 1/16 (2018.01); C12Q 1/6876 (2013.01); G01N 33/5067 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/726 (2013.01);
Abstract
The present invention derives from the unexpected finding that ADRA2a antagonists decrease fibrosis in non-alcoholic fatty liver disease (NAFLD). Thus, by antagonising ADRA2a, many of the unwanted consequences or symptoms of NAFLD, may be reduced, such as impaired cognitive activity and fibrosis progression. The present invention utilises these findings to identify and provide ADRA2a antagonists that may be used in the treatment of fibrosis in NAFLD.