The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2025
Filed:
Jun. 27, 2022
Applicant:
Queen's University AT Kingston, Kingston, CA;
Inventors:
Rebecca Grange, Kingston, CA;
John Allingham, Kingston, CA;
Andrew Craig, Kingston, CA;
P. Andrew Evans, Kingston, CA;
Madhu Aeluri, Kingston, CA;
Assignee:
Queen's University at Kingston, Kingston, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/45 (2006.01); A61K 31/221 (2006.01); A61K 31/25 (2006.01); A61K 31/341 (2006.01); A61K 31/397 (2006.01); A61K 31/4015 (2006.01); A61K 45/06 (2006.01); A61K 47/36 (2006.01); C07C 235/28 (2006.01); C07C 321/10 (2006.01); C07D 205/08 (2006.01); C07D 207/27 (2006.01); C07D 211/76 (2006.01); C07D 307/46 (2006.01);
U.S. Cl.
CPC ...
A61K 31/45 (2013.01); A61K 31/221 (2013.01); A61K 31/25 (2013.01); A61K 31/341 (2013.01); A61K 31/397 (2013.01); A61K 31/4015 (2013.01); A61K 45/06 (2013.01); A61K 47/36 (2013.01); C07C 235/28 (2013.01); C07C 321/10 (2013.01); C07D 205/08 (2013.01); C07D 207/27 (2013.01); C07D 211/76 (2013.01); C07D 307/46 (2013.01);
Abstract
A class of compounds useful in pharmaceutical compositions and methods for treating or preventing cancer is described. Analogs of Mycalolide B have been prepared and tested in breast and ovarian cancer cell lines. The compounds show utility for inhibition of survival and proliferation of tumor cells. The compounds have been shown to disrupt actin.