The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2025
Filed:
Dec. 06, 2019
The General Hospital Corporation, Boston, MA (US);
Martin L. Yarmush, Newton, MA (US);
Mehmet Toner, Wellesley, MA (US);
Maria-Louisa Izamis, Boston, MA (US);
Timothy Antonie Berendsen, Melrose, MA (US);
Robert Marius Bieganski, Cambridge, MA (US);
Osman Berk Usta, Watertown, MA (US);
Basak Elif Uygun, Newton, MA (US);
Mustafa Korkut Uygun, Newton, MA (US);
Sinem Perk, Chicago, IL (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and/or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage.