The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2025
Filed:
Mar. 17, 2022
Applicant:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Inventors:
Punit P. Seth, Carlsbad, CA (US);
Michael Oestergaard, Carlsbad, CA (US);
Michael T. Migawa, Carlsbad, CA (US);
Xue-Hai Liang, Del Mar, CA (US);
Wen Shen, Carlsbad, CA (US);
Stanley T. Crooke, Carlsbad, CA (US);
Eric E. Swayze, Encinitas, CA (US);
Assignee:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/10 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/10 (2013.01); C12N 15/113 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3231 (2013.01);
Abstract
The present disclosure provides oligomeric compound comprising a modified oligonucleotide having a central region comprising one or more modifications. In certain embodiments, the present disclosure provides oligomeric compounds having an improved therapeutic index or an increased maximum tolerated dose.