The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Dec. 31, 2019
Applicant:
Expansion Technologies, Boston, MA (US);
Inventor:
Mahender Babu Dewal, Arlington, MA (US);
Assignee:
EXPANSION TECHNOLOGIES, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
G01N 1/30 (2006.01); C09B 11/08 (2006.01); C09B 61/00 (2006.01); G01N 33/58 (2006.01); G02B 21/06 (2006.01); G02B 21/36 (2006.01);
U.S. Cl.
CPC ...
G01N 1/30 (2013.01); C09B 11/08 (2013.01); C09B 61/00 (2013.01); G01N 33/582 (2013.01); G01N 2001/302 (2013.01); G02B 21/06 (2013.01); G02B 21/36 (2013.01);
Abstract
A technique for expansion microscopy (ExM) utilizing anchorable derivatives of hematoxylin and eosin (H&E) stained tissue specimens within tissue samples, in order to achieve high resolution detection of biomolecules with precise morphological features of cells and nuclei, which in turn, allows for effective for accurate early stage disease diagnosis including various cancers. Staining with H&E employs anchorable derivatives that can be cross-linked into the ExM hydrogel matrix.