The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Mar. 09, 2022
Applicant:
The Trustees of Indiana University, Bloomington, IN (US);
Inventor:
Jaipal Singh, Carmel, IN (US);
Assignee:
THE TRUSTEES OF INDIANA UNIVERSITY, Bloomington, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/78 (2006.01); A61K 38/50 (2006.01);
U.S. Cl.
CPC ...
C12N 9/78 (2013.01); A61K 38/50 (2013.01); C12Y 305/03018 (2013.01);
Abstract
Modified DDAH polypeptides and their uses thereof are provided. Exemplary embodiments provide DDAH polypeptides which include one or more amino acid substitutions, additions, or deletions with natural or non-naturally encoded amino acids, and/or linkage to other biologically active molecules including other DDAH polypeptides, as well as PKEM. Additionally, use of said DDAH polypeptides for treatment of disease, such as heart failure or renal disease, is also provided.