The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Sep. 22, 2021
Applicant:
Vlp Therapeutics, Inc., Wilmington, DE (US);
Inventors:
Wataru Akahata, Kensington, MD (US);
Ryuji Ueno, Easton, MD (US);
Assignee:
VLP Therapeutics, Inc., Wilmington, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/005 (2006.01); C07K 16/28 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); A61K 39/001162 (2018.08); A61K 39/12 (2013.01); A61P 35/00 (2018.01); C07K 14/005 (2013.01); C07K 16/2818 (2013.01); C12N 15/86 (2013.01); A61K 48/00 (2013.01); C12N 2770/36122 (2013.01); C12N 2770/36123 (2013.01); C12N 2770/36134 (2013.01); C12N 2770/36143 (2013.01); C12N 2770/36152 (2013.01);
Abstract
Provided is an alphavirus replicon particle (ARP), which comprises (i) alphavirus structural proteins comprising capsid and/or envelope, and (ii) an alphavirus replicon comprising a polynucleotide encoding alphavirus non-structural proteins nsp1, nsp2, nsp3 and nap4 and at least one gene of interest wherein at least one of capsid, and E3 and E2 in the envelope comprise one or more amino acid alteration but E1 in the envelope comprises no amino acid alteration.