The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Oct. 23, 2018
The Broad Institute, Inc., Cambridge, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Amit Choudhary, Boston, MA (US);
Donghyun Lim, Cambridge, MA (US);
Kurt Cox, Cambridge, MA (US);
Soumyashree Ashok Gangopadhyay, Boston, MA (US);
The Broad Institute, Inc., Cambridge, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
The present inventions generally relate to site-specific delivery of nucleic acid modifiers and includes novel DNA-binding proteins and effectors that can be rapidly programmed to make site-specific DNA modifications. The present inventions also provide a synthetic all-in-one genome editor (SAGE) systems comprising designer DNA sequence readers and a set of small molecules that induce double-strand breaks, enhance cellular permeability, inhibit NHEJ and activate HDR, as well as methods of using and delivering such systems.