The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Dec. 02, 2022
University Health Network, Toronto, CA;
Sinai Health System, Toronto, CA;
Daniel Diniz De Carvalho, Toronto, CA;
Shu Yi Shen, Markham, CA;
Rajat Singhania, Toronto, CA;
Scott Victor Bratman, Toronto, CA;
Ankur Ravinarayana Chakravarthy, Toronto, CA;
University Health Network, Toronto, CA;
Sinai Health System, Toronto, CA;
Abstract
There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.