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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12227732 B1

PDFFull Text
Date of Patent:
Feb. 18, 2025

Filed:

Oct. 31, 2022

Systems for cell culture scaling

Applicant:

Life Technologies Corporation, Carlsbad, CA (US);

Inventors:

Christopher Brau, Grand Island, NY (US);

Nephi Jones, Newton, UT (US);

Mark Smith, Nibley, UT (US);

Assignee:

Life Technologies Corporation, Carlsbad, CA (US);

Attorney:

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.

Primary Examiner:

Anshu Bhatia

Int. Cl.
CPC ...
B01F 23/00 (2022.01); B01F 23/233 (2022.01); B01F 27/054 (2022.01); B01F 27/114 (2022.01); B01F 27/213 (2022.01); B01F 27/92 (2022.01); B01F 35/32 (2022.01); B01F 35/41 (2022.01); B01F 35/43 (2022.01); B01F 35/513 (2022.01); C12M 1/00 (2006.01); C12M 1/06 (2006.01); C12M 1/36 (2006.01); C12M 1/42 (2006.01); C12N 5/071 (2010.01); B01F 27/90 (2022.01); B01F 35/30 (2022.01); B01F 101/44 (2022.01);
U.S. Cl.
CPC ...
C12M 35/04 (2013.01); B01F 23/233 (2022.01); B01F 27/054 (2022.01); B01F 27/114 (2022.01); B01F 27/213 (2022.01); B01F 27/92 (2022.01); B01F 35/3204 (2022.01); B01F 35/4121 (2022.01); B01F 35/43 (2022.01); B01F 35/513 (2022.01); C12M 23/50 (2013.01); C12M 23/58 (2013.01); C12M 27/02 (2013.01); C12M 27/06 (2013.01); C12M 41/48 (2013.01); C12N 5/0602 (2013.01); B01F 23/23362 (2022.01); B01F 27/90 (2022.01); B01F 35/3214 (2022.01); B01F 2035/352 (2022.01); B01F 2101/44 (2022.01); C12N 2527/00 (2013.01);
Abstract

The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

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