The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Nov. 07, 2017
The Broad Institute, Inc., Cambridge, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Adam Haber, Cambridge, MA (US);
Moshe Biton, Cambridge, MA (US);
Rebecca H. Herbst, Cambridge, MA (US);
Karthik Shekhar, Cambridge, MA (US);
Christopher Smillie, Cambridge, MA (US);
Orit Rozenblatt-Rosen, Cambridge, MA (US);
Ramnik Xavier, Boston, MA (US);
Aviv Regev, Cambridge, MA (US);
Jose Ordovas-Montanes, Cambridge, MA (US);
Alexander K. Shalek, Cambridge, MA (US);
Noga Rogel, Cambridge, MA (US);
The Broad Institute, Inc., Cambridge, MA (US);
Massachussetts Institute of Technology, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
An atlas of intestinal epithelial cells, intestinal epithelial stem cells and intestinal immune cells identifies new cell populations, markers, networks, and responses to stimuli. Intestinal T cells drive intestinal epithelial cell differentiation and activity. Accordingly, disclosed are methods of modulating intestinal epithelial cell differentiation, maintenance and/or function, related methods for the treatment of disease, including IBD. Also disclosed are methods and kits for identifying cell types, their differentiation, homeostasis and activation.