The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Feb. 20, 2020
Joint Stock Company “biocad”, Saint Petersburg, RU;
Olga Vladimirovna Britanova, Moscow, RU;
Dmitry Borisovich Staroverov, Moscow, RU;
Anna Valentinovna Evstrateva, G. Pitkyaranta, RU;
Alexey Konstantinovich Misorin, Saint Petersburg, RU;
Timofey Aleksandrovich Nemankin, Saint Petersburg, RU;
Mariia Aleksandrovna Shchemeleva, Saint-Petersburg, RU;
Anna Konstantinovna Vladimirova, Saint Petersburg, RU;
Arina Vitalevna Anikina, Moscow, RU;
Roman Alekseevich Ivanov, Moscow, RU;
Dmitry Valentinovich Morozov, Saint Petersburg, RU;
Pavel Andreevich Iakovlev, Saint Petersburg, RU;
Sergey Anatolievich Lukyanov, Moscow, RU;
Abstract
The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.