The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Nov. 11, 2019
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Laurie H. Glimcher, Boston, MA (US);
Han Dong, Boston, MA (US);
Assignee:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C12N 5/0783 (2010.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12Q 1/6886 (2018.01);
U.S. Cl.
CPC ...
C07K 14/4705 (2013.01); A61K 39/4613 (2023.05); A61K 39/4644 (2023.05); A61K 39/464838 (2023.05); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C12N 5/0646 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12Q 1/6886 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/57 (2023.05); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01);
Abstract
The present invention is based, in part, on the identification of an IRE1α-XBP1-cMyc axis in NK cell immunity. The present invention provides compositions and methods for treating conditions that would benefit from modulating (e.g., upregulating or downregulating) an immune response using an agent that modulates the IRE1α-XBP1 pathway, or a composition comprising modified NK cells.