The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Sep. 19, 2022
Sloan Kettering Institute for Cancer Research, New York, NY (US);
David Gin, New York, NY (US);
Michelle Adams, Waterville, OH (US);
Kai Deng, Guilderland, NY (US);
Philip Livingston, New York, NY (US);
Govindaswami Ragupathi, New York, NY (US);
Eric Chea, Flushing, NY (US);
Alberto Fernandez-Tejada, New York, NY (US);
Lars Ulrik Nordstroem, New York, NY (US);
William Walkowicz, Brooklyn, NY (US);
Jeffrey Gardner, New York, NY (US);
Derek Tan, New York, NY (US);
Abstract
The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.