The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Dec. 16, 2021
Colorado State University Research Foundation, Fort Collins, CO (US);
Cetya Therapeutics, Inc., Fort Collins, CO (US);
Robert M. Williams, Ft. Collins, CO (US);
Sivanagireddy Koti, Ft. Collins, CO (US);
Subhadip De, Ft. Collins, CO (US);
Anil M. Shelke, Ft. Collins, CO (US);
Ryan E. Cerbone, Ft. Collins, CO (US);
Nobuyoshi Yasuda, Ft. Collins, CO (US);
COLORADO STATE UNIVERSITY RESEARCH FOUNDATION, Fort Collins, CO (US);
CETYA THERAPEUTICS, INC., Fort Collins, CO (US);
Abstract
Disclosed are various synthetic methods to prepare structural analogs of largazole and derivatives thereof. One structural analog is an amide isostere of largazole. Another structural analog replaces the thiazole ring of largazole with a pyridine moiety or an oxazole moiety. Also disclosed are various intermediate compounds obtained when preparing structural analogs of largazole and derivatives thereof, including macrocycle analogs having an alcohol functionality.