The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Dec. 03, 2019
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Alyssa Verano, Allston, MA (US);
Eric Wang, Brookline, MA (US);
Radoslaw Nowak, Boston, MA (US);
Jing Ting Christine Yuan, Brookline, MA (US);
Nathanael Gray, Boston, MA (US);
Eric Fischer, Chestnut Hill, MA (US);
Tinghu Zhang, Brookline, MA (US);
Hu Liu, Newton, MA (US);
Assignee:
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); A61P 35/00 (2006.01); C07D 401/14 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61P 35/00 (2018.01); C07D 401/14 (2013.01); C07D 417/14 (2013.01);
Abstract
Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders characterized or mediated by aberrant protein activity.