The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Apr. 03, 2020
Yuhan Corporation, Seoul, KR;
Sang-Ho Oh, Gunpo-si, KR;
Doo-Byung Lee, Yongin-si, KR;
Kyoung-Chan Kwon, Hwaseong-si, KR;
Sang-Won Kim, Hwaseong-si, KR;
Hyo-Ick Hwang, Suwon-si, KR;
Kyeong-Sill Lee, Hwaseong-si, KR;
Ik-Su Jo, Osan-si, KR;
Ji-Hye Choi, Suwon-si, KR;
Sung-Hee Cho, Suwon-si, KR;
Su-Young Lee, Hwaseong-si, KR;
YUHAN CORPORATION, Seoul, KR;
Abstract
Provided are a process for preparing (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine or a salt thereof, which is an intermediate useful for the preparation of tofacitinib, an intermediate used in the process, i.e., isopropanol solvate of methyl ((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)carbamate dibenzoyl-L-tartrate, an intermediate, having excellent stability, useful for the preparation of tofacitinib, i.e., (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine acetate, and a process for preparing tofacitinib or a pharmaceutically acceptable salt thereof.