Synergistically cooperative compositions useful for soft tissue augmentation, drug delivery and related fields

Abstract

The present invention relates to compositions based on: (a) a glycosaminoglycan or mixtures thereof; (b) one or more tocopherols, tocotrienols and mixtures thereof; and (c) a selected stabilizer. The composition is a solution, with the agents not chemically bound with each other. The component (a) can be hyaluronic acid (HA) or a salt thereof; the component (b) can be a polyether clathrate a cyclodextrin, or a combination of a fatty acid with an emulsifier; the component (c) can be α-tocopherols, β-tocopherols, γ-tocopherols, δ-tocopherols; α-tocotrienols, β-tocotrienols, γ-tocotrienols, δ-tocotrienols. Preferably component (c) is vitamin E. The agents strongly cooperate to provide enhanced and more stable viscoelastic properties, resulting in a product with higher resistance to thermal treatments like e.g. heat-sterilization, autoclaving, etc. The present compositions, optionally loaded with pharmaceutically and/or cosmetically active agents, are advantageously used in medical or cosmetic methods.