The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2025
Filed:
Nov. 30, 2021
Immunolight, Llc, Detroit, MI (US);
Duke University, Durham, NC (US);
Harold Walder, Oak Island, NC (US);
Frederic A. Bourke, Jr., Aspen, CO (US);
Zakaryae Fathi, Raleigh, NC (US);
Wayne F. Beyer, Ivanhoe, VA (US);
Mark Oldham, Durham, NC (US);
Justus Adamson, Durham, NC (US);
Michael Nolan, Raleigh, NC (US);
IMMUNOLIGHT, LLC, Detroit, MI (US);
DUKE UNIVERSITY, Durham, NC (US);
Abstract
A method for treating a disease in a subject in need thereof is provided involving infusing 8-methoxypsoralen (8-MOP) and a phosphor-containing drug activator into a diseased site in the subject; and delivering a dose of x-rays to the subject for production of the ultraviolet and visible light inside the subject to activate the photoactivatable drug and induce a persistent therapeutic response, the dose including a pulsed sequence of x-rays delivering from 0.5-2 Gy to the tumor, wherein the phosphor-containing drug activator includes an admixture of two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays; the two or more phosphors including ZnSiO:Mnand (3Ca(PO)Ca(F, Cl):Sb, Mn) at a ratio (ZnSiO:Mn):(3Ca(PO)Ca(F, Cl):Sb, Mn)) of from 1:10 to 10:1; wherein each of the two or more phosphors have at least one coating selected from an ethyl cellulose coating or a diamond-like carbon coating.